Channeled β-TCP Scaffolds Promoted Vascularization and Bone Augmentation in Mandible of Beagle Dogs

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 1 wileyonlinelibrary.com To prevent ridge resorption and postextraction alveolar bone loss, immediate or early implant placement procedures have become a key component and standard-ofcare treatment following tooth removal in clinical dentistry.[4] Several clinical techniques and many biomaterials have been introduced in an effort to preserve alveolar ridge and promote bone augmentation for following dental implants.[5–7] In these strategies, autologous bone grafts or allografts are extensively used for bone grafting of the socket in dentistry. However, limited supply, donor site morbidity, prolonged recovery, and complicated surgical procedures hamper their applications in immediate or early implant placement of a socket after tooth extraction.[8–10] A synthetic bone substitute Bio-Oss collagen has been extensively used for horizontal bone augmentation. However, clinical results indicated that its ability for vertical bone augmentation was insufficient, and that dental implants placed in bone augmented with Bio-Oss showed an increased failure rate and a prolonged healing time due to insufficient bone volume.[11] Although other synthetic biomaterials options as alternative solutions have been extensively studied to treat a variety of bone defects in the past decades,[12–14] none of the bone grafting options currently available to preserve alveolar ridge and bone augmentation have an ideal outcome.[15,16] Channeled β-TCP Scaffolds Promoted Vascularization and Bone Augmentation in Mandible of Beagle Dogs